KMID : 0032220110230040497
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Annals of Dermatology 2011 Volume.23 No. 4 p.497 ~ p.500
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Wells¡¯ Syndrome Associated with Churg-Strauss Syndrome
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Lee Soo-Hyun
Roh Mi-Ryung Jee Hyun-Joong Chung Kee-Yang Jung Jin-Young
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Abstract
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Churg-Strauss syndrome (CSS) is a multisystem granulomatous vasculitis that is characterized by peripheral eosinophilia and the infiltration of eosinophils into systemic organs. The skin lesions of CSS consist mainly of palpable purpura and nodules. Wells¡¯ syndrome (WS) is a rare inflammatory dermatosis that is associated with recurrent granulomatous dermatitis and eosinophilia. Since these two diseases are rare, any overlap between them is very unusual. Herein, we report a patient with CSS, who initially presented a skin eruption of erythematous urticarial-plaques, vesicles, and blisters. Upon biopsy, the histology of these plaques indicated eosinophilic infiltration and "flame figures" within the dermis, which was consistent with a diagnosis of WS. Although the association between WS and CSS that was observed in our patient may be purely coincidental, it could also suggest a common pathogenetic background of these two distinct diseases, as both share several many common features.
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KEYWORD
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Churg-Strauss syndrome, Flame figures, Wells¡¯ syndrome
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